Huntington Disease (HD)

▪️It is a progressive genetic disorder which affects the brain. 

▪️It causes uncontrolled movements, impaired coordination of balance and movement, a decline in cognitive abilities, difficulty in concentrating and memory lapses, mood swings and personality changes. 

▪️The HTT genes are involved in the production of a protein called huntingtin. They provide the instruction for making the protein.

▪️Mutated genes provide faulty instructions leading to production of abnormal huntingtin proteins and formation of clumps.

▪️These clumps disrupt the normal functioning of the brain cells, which eventually leads to death of neurons in the brain, resulting in Huntington disease.

▪️No cure exists, but drugs, physiotherapy and talk therapy can help manage some symptoms.